• May 4, 2021


Engman C, Wen Y, Meng W, Bottino R, Trucco M, Giannoukakis N. Generation of antigen-specific Foxp3+ regulatory T-cells in vivo following administration of diabetes-reversing tolerogenic microspheres does not require provision of antigen in the formulation. Clin Immunol. 2015 Sep:160(1):103-23. doi: 10.1016/j.clim.2015.03.004. PubMed PMID: 25773782.

di Caro V, Phillips B, Engman C, Harnaha J, Trucco M, Giannoukakis N. Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice. PLOS One. 2014 Jan; doi: 10.2271/journal.pone.0083575. PubMed PMCID: PMC3894962.

Creusot R, Giannoukakis N, Trucco M, Clare-Salzler M, Garrison Fathman C. It’s time to bring dendritic cell therapy to type 1 diabetes. Diabetes. 2014 Jan;64(1):20-30. doi: 10.2337/db13-0886. PubMed PMID: 24357690.

Giannoukakis N, Trucco M. Dendritic cell therapy for Type 1 diabetes suppression. Immunotherapy. 2012 Oct;4(10):1063-74. doi: 10.2217/imt.12.76. PubMed PMID: 23148758.

Giannoukakis N, Trucco M. A role for tolerogenic dendritic cell-induced B-regulatory cells in type 1 diabetes mellitus. Curr Opin Endocrinol Diabetes Obes. 2012 Aug;19(4):279-87. doi: 10.1097/MED.0b013e328355461b. Review. PubMed PMID: 22760513.

Grupillo M, Gualtierotti G, He J, Sisino G, Bottino R, Rudert WA, Trucco M, Fan Y. Essential roles of insulin expression in Aire+ tolerogenic dendritic cells in maintaining peripheral self-tolerance of islet β-cells. Cell Immunol. 2012;273(2):115-23. doi: 10.1016/j.cellimm.2011.12.010. Epub 2012 Jan 12. PubMed PMID: 22297234.

Phillips BE, Trucco M. Immunotherapy-based strategies for the treatment of autoimmune diabetes: searching for the cure. Curr Pharm Des. 2011;17(29):3217-23. Review. PubMed PMID: 21864264.

Phillips B, Trucco M, Giannoukakis N. Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same? Clin Dev Immunol. 2011;2011:432016. doi: 10.1155/2011/432016. Epub 2011 Jul 18. Review. PubMed PMID: 21785616; PubMed Central PMCID: PMC3139873.

Giannoukakis N, Phillips B, Finegold D, Harnaha J, Trucco M. Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care. 2011 Sep;34(9): 2026-32. doi: 10.2337/dc11-0472. Epub 2011 Jun 16. PubMed PMID: 21680720; PubMed Central PMCID: PMC3161299.

Di Caro V, D’Anneo A, Phillips B, Engman C, Harnaha J, Trucco M, Giannoukakis N. Phosphatidylinositol-3-kinase activity during in vitro dendritic cell generation determines suppressive or stimulatory capacity. Immunol Res. 2011 Aug;50(2-3):130-52. doi: 10.1007/s12026-011-8206-1. PubMed PMID: 21476100.

Trucco M. Beta-cell regeneration: from science fiction to challenging reality. Pediatr Diabetes. 2010 Aug;11(5):292-5. doi: 10.1111/j.1399-5448.2010.00704.x. PubMed PMID: 20646239.

Trucco M. Gene-environment interaction in type 1 diabetes mellitus. Endocrinol Nutr. 2009 Dec;56 Suppl 4:56-9. Review. PubMed PMID: 20629235.

Phillips B, Giannoukakis N, Trucco M. Dendritic cell-based therapy in Type 1 diabetes mellitus. Expert Rev Clin Immunol. 2009 May;5(3):325-39. doi: 10.1586/eci.09.8. PubMed PMID: 20477010.

Schulte BM, Kramer M, Ansems M, Lanke KH, van Doremalen N, Piganelli JD, Bottino R, Trucco M, Galama JM, Adema GJ, van Kuppeveld FJ. Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells. Diabetes. 2010 May;59(5):1182-91. doi: 10.2337/db09-1071. Epub 2010 Jan 13. PubMed PMID: 20071599; PubMed Central PMCID: PMC2857898.

Phillips BE, Giannoukakis N, Trucco M. Dendritic cell mediated therapy for immunoregulation of type 1 diabetes mellitus. Pediatr Endocrinol Rev. 2008 Jun;5(4):873-9. Review. PubMed PMID: 18552749.

Giannoukakis N, Phillips B, Trucco M. Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond. Pediatr Diabetes. 2008 Jun;9(3 Pt 2):4-13. doi: 10.1111/j.1399-5448.2008.00401.x. PubMed PMID: 18540865.

Phillips B, Nylander K, Harnaha J, Machen J, Lakomy R, Styche A, Gillis K, Brown L, Lafreniere D, Gallo M, Knox J, Hogeland K, Trucco M, Giannoukakis N. A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes. Diabetes. 2008 Jun;57(6):1544-55. doi: 10.2337/db07-0507. Epub 2008 Mar 3. PubMed PMID: 18316361; PubMed Central PMCID: PMC2713034.

Pasquali L, Giannoukakis N, Trucco M. Induction of immune tolerance to facilitate beta cell regeneration in type 1 diabetes. Adv Drug Deliv Rev. 2008 Jan 14;60(2):106-13. Epub 2007 Oct 9. Review. PubMed PMID: 18053613.

Li J, Meinhardt A, Roehrich ME, Golshayan D, Dudler J, Pagnotta M, Trucco M, Vassalli G. Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3415-23. Epub 2007 Oct 12. PubMed PMID: 17933973.

Trucco M, Giannoukakis N. Immunoregulatory dendritic cells to prevent and reverse new-onset Type 1 diabetes mellitus. Expert Opin Biol Ther. 2007 Jul;7(7):951-63. Review. PubMed PMID: 17665986.

Liu Z, Dai H, Wan N, Wang T, Bertera S, Trucco M, Dai Z. Suppression of memory CD8 T cell generation and function by tryptophan catabolism. J Immunol. 2007 Apr 1;178(7):4260-6. PubMed PMID: 17371982.

Harnaha J, Machen J, Wright M, Lakomy R, Styche A, Trucco M, Makaroun S, Giannoukakis N. Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells. Diabetes. 2006 Jan:55(1):158-70. PubMed PMID: 16380489.

Perone MJ, Bertera S, Tawadrous ZS, Shufesky WJ, Piganelli JD, Baum LG, Trucco M, Morelli AE. Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol. 2006 Oct 15;177(8):5278-89. PubMed PMID: 17015713.

Pasquali L, Fan Y, Trucco M, Ringquist S. Rehabilitation of adaptive immunity and regeneration of beta cells. Trends Biotechnol. 2006 Nov;24(11):516-22. Epub 2006 Sep 11. Review. PubMed PMID: 16963140.

Conrad B, Weidmann E, Trucco G, Rudert WA, Behboo R, Ricordi C, Rodriquez-Rilo H, Finegold D, Trucco M. Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Nature. 1994 Sep 22;371(6495):351-5. PubMed PMID: 8090207.

Rilo HL, Carroll PB, Trucco M, Phipps J, Trucco G, Finegold D, Ricordi C. Human pancreatic islet isolation from a diabetic non-heart-beating donor. Transplant Proc. 1994 Apr;26(2):598. PubMed PMID: 8171575.