Hallmarks of cancer: the next generation.
Hallmarks of cancer: the next generation.
The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions.
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Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list-reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the “tumor microenvironment.” Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described. The method provides a pure preparation of undegraded RNA in high yield and can be completed within 4 h. It is particularly useful for processing large numbers of samples and for isolation of RNA from minute quantities of cells or tissue samples.
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was dispensable. These cells, which we designated iPS (induced pluripotent stem) cells, exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
Subcutaneous transplantation of iPS cells into nude mice resulted in tumors containing a variety of tissues from all three germ layers. Following injection into blastocysts, iPS cells contributed to mouse embryonic development. These data demonstrate that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors.
Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.
The steady-state basal plasma glucose and insulin concentrations are determined by their interaction in a feedback loop. A computer-solved model has been used to predict the homeostatic concentrations which arise from varying degrees beta-cell deficiency and insulin resistance. Comparison of a patient’s fasting values with the model’s predictions allows a quantitative assessment of the contributions of insulin resistance and deficient beta-cell function to the fasting hyperglycaemia (homeostasis model assessment, HOMA). The accuracy and precision of the estimate have been determined by comparison with independent measures of insulin resistance and beta-cell function using hyperglycaemic and euglycaemic clamps and an intravenous glucose tolerance test.
The estimate of insulin resistance obtained by homeostasis model assessment correlated with estimates obtained by use of the euglycaemic clamp (Rs = 0.88, p less than 0.0001), the fasting insulin concentration (Rs = 0.81, p less than 0.0001), and the hyperglycaemic clamp, (Rs = 0.69, p less than 0.01). There was no correlation with any aspect of insulin-receptor binding. The estimate of deficient beta-cell function obtained by homeostasis model assessment correlated with that derived using the hyperglycaemic clamp (Rs = 0.61, p less than 0.01) and with the estimate from the intravenous glucose tolerance test (Rs = 0.64, p less than 0.05).
The low precision of the estimates from the model (coefficients of variation: 31% for insulin resistance and 32% for beta-cell deficit) limits its use, but the correlation of the model’s estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation. The assay detects living, but not dead cells and the signal generated is dependent on the degree of activation of the cells. This method can therefore be used to measure cytotoxicity, proliferation or activation.
The results can be read on a multiwell scanning spectrophotometer (ELISA reader) and show a high degree of precision. No washing steps are used in the assay. The main advantages of the colorimetric assay are its rapidity and precision, and the lack of any radioisotope. We have used the assay to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.
The Agrobacterium vacuum infiltration method has made it possible to transform Arabidopsis thaliana without plant tissue culture or regeneration. In the present study, this method was evaluated and a substantially modified transformation method was developed. The labor-intensive vacuum infiltration process was eliminated in favor of simple dipping of developing floral tissues into a solution containing
Agrobacterium tumefaciens, 5% sucrose and 500 microliters per litre of surfactant Silwet L-77. Sucrose and surfactant were critical to the success of the floral dip method. Plants inoculated when numerous immature floral buds and few siliques were present produced transformed progeny at the highest rate. Plant tissue culture media, the hormone benzylamino purine and pH adjustment were unnecessary, and Agrobacterium could be applied to plants at a range of cell densities. Repeated application of Agrobacterium improved transformation rates and overall yield of transformants approximately twofold.
Covering plants for 1 day to retain humidity after inoculation also raised transformation rates twofold. Multiple ecotypes were transformable by this method. The modified method should facilitate high-throughput transformation of Arabidopsis for efforts such as T-DNA gene tagging, positional cloning, or attempts at targeted gene replacement.
anti- Betacellulin antibody |
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| FNab00883 | FN Test | 100µg | EUR 606.3 |
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Description: Antibody raised against Betacellulin |
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Human Betacellulin CLIA Kit |
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| MBS8425178-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human Betacellulin |
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| 7-00223 | CHI Scientific | 5µg | Ask for price |
Recombinant Human Betacellulin |
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| 7-00224 | CHI Scientific | 20µg | Ask for price |
Recombinant Human Betacellulin |
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| 7-00225 | CHI Scientific | 1mg | Ask for price |
Human Betacellulin (Recombinant) |
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| 22060316-1 | Glycomatrix | 5 µg | EUR 146.42 |
Recombinant Human Betacellulin |
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| AP60110 | SAB | 100ug | EUR 896 |
Recombinant Human BetaCellulin |
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| HEOPP-0212 | Cyagen | 5ug | Ask for price |
Recombinant Human Betacellulin |
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| cyt-330-1mg | ProSpec Tany | 1mg | EUR 2700 |
Recombinant Human Betacellulin |
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| cyt-330-20g | ProSpec Tany | 20µg | EUR 145 |
Recombinant Human Betacellulin |
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| cyt-330-5g | ProSpec Tany | 5µg | EUR 60 |
Recombinant Human Betacellulin |
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| MBS142207-0005mg | MyBiosource | 0.005mg | EUR 240 |
Recombinant Human Betacellulin |
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| MBS142207-002mg | MyBiosource | 0.02mg | EUR 310 |
Recombinant Human Betacellulin |
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| MBS142207-1mg | MyBiosource | 1mg | EUR 2880 |
Recombinant Human Betacellulin |
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| MBS142207-5x1mg | MyBiosource | 5x1mg | EUR 12630 |
Recombinant Human Betacellulin |
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| P1308-.005 | ApexBio | 5ug | EUR 108.8 |
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Description: Peptides & Proteins|Recombinant Proteins |
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Recombinant Human Betacellulin |
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| P1308-.1 | ApexBio | 100ug | EUR 900 |
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Description: Peptides & Proteins|Recombinant Proteins |
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Recombinant Human Betacellulin |
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| P1308-.5 | ApexBio | 500ug | EUR 2021.6 |
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Description: Peptides & Proteins|Recombinant Proteins |
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Human Betacellulin ELISA KIT |
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| E42EH-268 | EnoGene | 96T/48T | Ask for price |
Human Betacellulin ELISA Kit |
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| MBS009811-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Human Betacellulin ELISA Kit |
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| MBS009811-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Human Betacellulin ELISA Kit |
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| MBS009811-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Human Betacellulin ELISA Kit |
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| MBS009811-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Human Betacellulin ELISA Kit |
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| IHUBTCKT | Innovative research | each | EUR 702 |
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Description: Human Betacellulin ELISA Kit |
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Human Betacellulin ELISA Kit |
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| GWB-SKR006 | GenWay Biotech | 96 Tests | Ask for price |
Human betacellulin ELISA Kit |
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| MBS727932-48StripWellsCompetitive | MyBiosource | 48-Strip-Wells-(Competitive) | EUR 485 |
Human betacellulin ELISA Kit |
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| MBS727932-48StripWellsSandwich | MyBiosource | 48-Strip-Wells-(Sandwich) | EUR 485 |
Human betacellulin ELISA Kit |
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| MBS727932-5x96StripWellsCompetitive | MyBiosource | 5x96-Strip-Wells-(Competitive) | EUR 3020 |
Human betacellulin ELISA Kit |
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| MBS727932-96StripWellsCompetitive | MyBiosource | 96-Strip-Wells-(Competitive) | EUR 690 |
Human betacellulin ELISA Kit |
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| MBS727932-96StripWellsSandwich | MyBiosource | 96-Strip-Wells-(Sandwich) | EUR 690 |
Human Betacellulin ELISA Kit |
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| MBS763506-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3900 |
Human Betacellulin ELISA Kit |
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| MBS763506-48StripWells | MyBiosource | 48-Strip-Wells | EUR 340 |
Human Betacellulin ELISA Kit |
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| MBS763506-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2045 |
Human Betacellulin ELISA Kit |
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| MBS763506-96StripWells | MyBiosource | 96-Strip-Wells | EUR 455 |
Human Betacellulin ELISA Kit |
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| MBS824733-5x96Tests | MyBiosource | 5x96Tests | EUR 2880 |
Human Betacellulin ELISA Kit |
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| MBS824733-96Tests | MyBiosource | 96Tests | EUR 645 |
Human Betacellulin ELISA Kit |
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| MBS138113-1Kit | MyBiosource | 1Kit | EUR 755 |
Human Betacellulin ELISA Kit |
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| MBS138113-5x1Kit | MyBiosource | 5x1Kit | EUR 3455 |
Betacellulin Human Recombinant |
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| rAP-0363 | Angio Proteomie | Inquiry | Ask for price |
Betacellulin, Recombinant, Human |
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| MBS650210-0005mg | MyBiosource | 0.005mg | EUR 340 |
Betacellulin, Recombinant, Human |
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| MBS650210-002mg | MyBiosource | 0.02mg | EUR 490 |
Betacellulin, Recombinant, Human |
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| MBS650210-5x002mg | MyBiosource | 5x0.02mg | EUR 2055 |
Betacellulin (Human) ELISA Kit |
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| EKA51822-5x96T | Biomatik Corporation | 5x96T | Ask for price |
Betacellulin (Human) ELISA Kit |
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| EKA51822-96T | Biomatik Corporation | 96T | EUR 446.9 |
Human Betacellulin (bTC) Protein |
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| 20-abx065524 | Abbexa |
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Human Betacellulin (bTC) Protein |
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| abx065524-100g | Abbexa | 100 µg | EUR 537.5 |
Human Betacellulin (bTC) Protein |
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| abx065524-10g | Abbexa | 10 µg | EUR 212.5 |
Human Betacellulin (bTC) Protein |
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| abx065524-50g | Abbexa | 50 µg | EUR 375 |
Human Betacellulin GENLISA ELISA |
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| KB1015 | Krishgen | 1 x 96 wells | EUR 198 |
Human Betacellulin (bTC) CLIA Kit |
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| abx196482-96tests | Abbexa | 96 tests | EUR 990 |
Human Betacellulin (BTC) CLIA Kit |
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| 20-abx491043 | Abbexa |
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Human Betacellulin (bTC) CLIA Kit |
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| abx196482-100l | Abbexa | 100 µl | Ask for price |
Human Betacellulin (bTC) CLIA Kit |
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| abx196482-50l | Abbexa | 50 µl | EUR 618.75 |
Human Betacellulin (BTC) ELISA Kit |
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| abx250182-96tests | Abbexa | 96 tests | EUR 801.6 |
Human Betacellulin (BTC) ELISA Kit |
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| abx570040-96tests | Abbexa | 96 tests | EUR 801.6 |
Human Betacellulin (bTC) ELISA Kit |
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| DLR-bTC-Hu | DL Develop | 96T | EUR 422 |
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Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| DLR-bTC-Hu-48T | DL Develop | 48T | EUR 574.8 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| DLR-bTC-Hu-96T | DL Develop | 96T | EUR 745.2 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| EKN43808-48T | Biomatik Corporation | 48T | EUR 341.04 |
Human Betacellulin (bTC) ELISA Kit |
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| EKN43808-5x96T | Biomatik Corporation | 5x96T | EUR 2314.2 |
Human Betacellulin (bTC) ELISA Kit |
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| EKN43808-96T | Biomatik Corporation | 96T | EUR 487.2 |
Human Betacellulin (bTC) ELISA Kit |
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| EKU02697-48T | Biomatik Corporation | 48T | EUR 500.5 |
Human Betacellulin (bTC) ELISA Kit |
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| EKU02697-5x96T | Biomatik Corporation | 5x96T | EUR 3396.25 |
Human Betacellulin (bTC) ELISA Kit |
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| EKU02697-96T | Biomatik Corporation | 96T | EUR 715 |
Human Betacellulin (bTC) ELISA Kit |
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| DL-bTC-Hu | DL Develop | 96T | EUR 402 |
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Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
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Human Betacellulin, BTC ELISA Kit |
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| DEIA089 | Creative Diagnostics | 10 plates | EUR 3126 |
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Description: This assay is a sandwich Enzyme Linked-Immuno-Sorbent Assay (ELISA). It is developed for quantitative measurement of human BTC in serum, plasma and other biological fluids. |
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Human Betacellulin/BTC ELISA kit |
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| E22-HC017.48 | EnoGene | 48T | EUR 295 |
Human Betacellulin/BTC ELISA kit |
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| E22-HC017.96 | EnoGene | 96T | EUR 395 |
Human Betacellulin (bTC) ELISA Kit |
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| EK12923 | SAB | 96Т | EUR 768 |
Human Betacellulin/BTC ELISA Kit |
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| EK5454 | SAB | 96 tests | EUR 599 |
Human Betacellulin (bTC) ELISA Kit |
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| SEA112Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5128.02 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| SEA112Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 527.48 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| SEA112Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 702.12 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| SEA112Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2799.54 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| 4-SEA112Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Betacellulin (bTC) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species. |
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Human Betacellulin(BTC)ELISA Kit |
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| YLA3880HU-48T | Shanghai YL Biotech | 48T | Ask for price |
Human Betacellulin(BTC)ELISA Kit |
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| YLA3880HU-96T | Shanghai YL Biotech | 96T | Ask for price |
Human Betacellulin/BTC ELISA Kit |
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| LF-EK50996 | Abfrontier | 1×96T | EUR 777.6 |
Human Betacellulin (bTC) ELISA Kit |
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| RD-bTC-Hu-48T | Reddot Biotech | 48T | EUR 411.8 |
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Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| RD-bTC-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 573.6 |
Human Betacellulin (bTC) ELISA Kit |
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| RD-bTC-Hu-96T | Reddot Biotech | 96T | EUR 588.3 |
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Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| RD-bTC-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 794.4 |
Human Betacellulin (bTC) ELISA Kit |
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| RDR-bTC-Hu-48T | Reddot Biotech | 48T | EUR 432.39 |
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Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| RDR-bTC-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 600 |
Human Betacellulin (bTC) ELISA Kit |
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| RDR-bTC-Hu-96T | Reddot Biotech | 96T | EUR 617.72 |
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Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| RDR-bTC-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 830.4 |
Human Betacellulin/BTC ELISA Kit |
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| MBS8579158-48Tests | MyBiosource | 48Tests | EUR 390 |
Human Betacellulin/BTC ELISA Kit |
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| MBS8579158-5x96Tests | MyBiosource | 5x96Tests | EUR 2275 |
Human Betacellulin/BTC ELISA Kit |
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| MBS8579158-96Tests | MyBiosource | 96Tests | EUR 495 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2020247-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 4910 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2020247-24StripWells | MyBiosource | 24-Strip-Wells | EUR 340 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2020247-48StripWells | MyBiosource | 48-Strip-Wells | EUR 500 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2020247-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2675 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2020247-96StripWells | MyBiosource | 96-Strip-Wells | EUR 665 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS452002-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 4700 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS452002-48StripWells | MyBiosource | 48-Strip-Wells | EUR 410 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS452002-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2410 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS452002-96StripWells | MyBiosource | 96-Strip-Wells | EUR 545 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2701248-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 2830 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2701248-24StripWells | MyBiosource | 24-Strip-Wells | EUR 240 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2701248-48StripWells | MyBiosource | 48-Strip-Wells | EUR 315 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2701248-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1480 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2701248-96StripWells | MyBiosource | 96-Strip-Wells | EUR 385 |
Human Betacellulin (BTC) ELISA Kit |
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| MBS2610656-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3040 |
Human Betacellulin (BTC) ELISA Kit |
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| MBS2610656-48StripWells | MyBiosource | 48-Strip-Wells | EUR 285 |
Human Betacellulin (BTC) ELISA Kit |
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| MBS2610656-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1670 |
Human Betacellulin (BTC) ELISA Kit |
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| MBS2610656-96StripWells | MyBiosource | 96-Strip-Wells | EUR 405 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS457991-10x96Tests | MyBiosource | 10x96Tests | EUR 4890 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS457991-48Tests | MyBiosource | 48Tests | EUR 425 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS457991-5x96Tests | MyBiosource | 5x96Tests | EUR 2495 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS457991-96Tests | MyBiosource | 96Tests | EUR 560 |
Human Betacellulin(BTC) ELISA Kit |
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| EIA07641h | Enlibio | each | EUR 430 |
Recombinant Human Betacellulin, HEK |
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| cyt-1188-10g | ProSpec Tany | 10µg | EUR 145 |
Recombinant Human Betacellulin, HEK |
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| cyt-1188-1mg | ProSpec Tany | 1mg | EUR 5200 |
Recombinant Human Betacellulin, HEK |
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| cyt-1188-2g | ProSpec Tany | 2µg | EUR 60 |
Recombinant Human Betacellulin, HEK |
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| MBS147328-0002mg | MyBiosource | 0.002mg | EUR 240 |
Recombinant Human Betacellulin, HEK |
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| MBS147328-001mg | MyBiosource | 0.01mg | EUR 310 |
Recombinant Human Betacellulin, HEK |
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| MBS147328-1mg | MyBiosource | 1mg | EUR 5345 |
Recombinant Human Betacellulin, HEK |
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| MBS147328-5x1mg | MyBiosource | 5x1mg | EUR 23725 |
Anti-BTC/Betacellulin Antibody |
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| MBS2400715-005mg | MyBiosource | 0.05mg | EUR 595 |
Anti-BTC/Betacellulin Antibody |
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| MBS2400715-5x005mg | MyBiosource | 5x0.05mg | EUR 2500 |
Human BTC -Betacellulin- CLIA Kit |
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| E-CL-H0444-24Tests | Elabscience Biotech | 24 Tests | EUR 180 |
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Description: Sandwich |
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Human BTC -Betacellulin- CLIA Kit |
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| E-CL-H0444-48Tests | Elabscience Biotech | 48 Tests | EUR 546 |
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Description: Sandwich |
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Human BTC -Betacellulin- CLIA Kit |
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| E-CL-H0444-96Tests | Elabscience Biotech | 96 Tests | EUR 682 |
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Description: Sandwich |
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Human BTC -Betacellulin- CLIA Kit |
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| E-CL-H0444-96Tests10 | Elabscience Biotech | 96 Tests *10 | EUR 6820 |
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Description: Sandwich |
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Human BTC -Betacellulin- CLIA Kit |
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| E-CL-H0444-96Tests5 | Elabscience Biotech | 96 Tests *5 | EUR 3410 |
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Description: Sandwich |
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Human bTC (Betacellulin) CLIA Kit |
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| MBS2531178-5x96Tests | MyBiosource | 5x96Tests | EUR 2565 |
Human bTC (Betacellulin) CLIA Kit |
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| MBS2531178-96Tests | MyBiosource | 96Tests | EUR 560 |
Human Betacellulin Protein, Fc Tag |
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| BEN-H525x | ACROBIOSYSTEMS | 1mg | EUR 374.5 |
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Description: Human Betacellulin, Fc Tag (BEN-H525x) is expressed from human 293 cells (HEK293). It contains AA Asp 32 - Tyr 111 (Accession # AAH11618). |
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Human BTC(Betacellulin) ELISA Kit |
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| EH0044 | FN Test | 96T | EUR 628.92 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml |
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Human BTC (Betacellulin) ELISA Kit |
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| EKE60392-5x96T | Biomatik Corporation | 5x96T | EUR 3124.08 |
Human BTC (Betacellulin) ELISA Kit |
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| EKE60392-96T | Biomatik Corporation | 96T | EUR 657.7 |
Human bTC(Betacellulin) ELISA Kit |
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| ELK1403-48T | ELK Biotech | 48T | Ask for price |
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Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human bTC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human bTC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human bTC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human bTC in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Human bTC(Betacellulin) ELISA Kit |
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| ELK1403-96T | ELK Biotech | 96T | Ask for price |
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Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human bTC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human bTC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human bTC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human bTC in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Human BTC(Betacellulin) ELISA Kit |
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| RE2928H-48wells | Reed Biotech | 48 wells | EUR 116.55 |
Human BTC(Betacellulin) ELISA Kit |
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| RE2928H-96wells | Reed Biotech | 96 wells | EUR 161.55 |
Human bTC (Betacellulin) ELISA Kit |
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| MBS8800404-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3130 |
Human bTC (Betacellulin) ELISA Kit |
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| MBS8800404-48StripWells | MyBiosource | 48-Strip-Wells | EUR 350 |
Human bTC (Betacellulin) ELISA Kit |
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| MBS8800404-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1710 |
Human bTC (Betacellulin) ELISA Kit |
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| MBS8800404-96StripWells | MyBiosource | 96-Strip-Wells | EUR 445 |
Human bTC (Betacellulin) ELISA Kit |
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| MBS2505147-10x96Tests | MyBiosource | 10x96Tests | EUR 4060 |
Human bTC (Betacellulin) ELISA Kit |
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| MBS2505147-24Tests | MyBiosource | 24Tests | EUR 265 |
Human bTC (Betacellulin) ELISA Kit |
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| MBS2505147-48Tests | MyBiosource | 48Tests | EUR 450 |
Human bTC (Betacellulin) ELISA Kit |
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| MBS2505147-5x96Tests | MyBiosource | 5x96Tests | EUR 2265 |
Human bTC (Betacellulin) ELISA Kit |
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| MBS2505147-96Tests | MyBiosource | 96Tests | EUR 535 |
Human BTC(Betacellulin) ELISA Kit |
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| RE2928H-48wellsplate | Reed Biotech | 48 wells plate | EUR 126 |
Human BTC(Betacellulin) ELISA Kit |
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| RE2928H-96wellsplate | Reed Biotech | 96 wells plate | EUR 180 |
Anti-Mouse Betacellulin Antibody |
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| 103-M308 | ReliaTech | 100 µg | EUR 399 |
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Description: Betacellulin (BTC) is a new member of the EGF family of cytokines that is comprised of at least ten proteins including EGF, TGFα, amphiregulin, HB-EGF, and the various heregulins. All of these cytokines are synthesized as transmembrane precursors and are characterized by the presence of one or more EGF structural units in their extracellular domain. The soluble forms of these cytokines are released by proteolytic cleavage. BTC, a heparin binding protein, was originally isolated from the conditioned media of mouse pancreatic beta tumor cells as a 32 kDa glycoprotein composed of 80 amino acid residues. The cDNA encoding human BTC was cloned from a human breast adenocarcinoma cell line (MCF7) cDNA library. Human and mouse cDNAs encode BTC precursor proteins of 178 and 177 amino acid residues, respectively. At the amino acid sequence level, human BTC precursor protein exhibits 79% identity with that of the mouse BTC precursor. In a mouse cell line transfected with human BTC cDNA, three forms of soluble human BTC have been detected: the glycosylated, intact BTC composed of 80 amino acid residues, a truncated molecule lacking 12 amino acid residues from the amino terminus, and a second truncated molecule lacking 30 amino acid residues from the amino-terminus. The biological activities of these BTC forms were shown to be identical. BTC can bind to the EGF receptor and is a potent mitogen for Balb/c 3T3 fibroblasts, retinal pigment epithelial cells and vascular smooth muscle cells. |
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BTC (untagged)-Human betacellulin (BTC) |
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| SC309035 | Origene Technologies GmbH | 10 µg | Ask for price |
Human Betacellulin Recombinant Protein |
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| 100-332 | ReliaTech | 20 µg | EUR 196.35 |
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Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein. |
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Human Betacellulin Recombinant Protein |
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| 100-332S | ReliaTech | 5 µg | EUR 92.4 |
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Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein. |
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Recombinant Human Betacellulin Protein |
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| PROTP35070-2 | BosterBio | 20ug | EUR 380.4 |
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Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein. |
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Recombinant Human Betacellulin protein |
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| CD02256-5ug | Jiaxing Korain Biotech Ltd (BT Labs) | 5ug | EUR 176 |
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Description: Betacellulin (BTC) is a member of the EGF family of cytokines that also includes EGF, TGF-a, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin and the Neuregulins. It is expressed in most tissues including kidney, uterus, liver and pancreas. BTC also presents in body fluids, including serum, milk, and colostrum. At the amino acid sequence level, human mature BTC protein exhibits 80 % identity with mouse BTC protein. The protein binds to EGFR, ERBB4 and other EGF receptor family members and acts as a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. |
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Betacellulin (bTC) Polyclonal Antibody (Human) |
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| 4-PAA112Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC) |
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Betacellulin (Human) LumiAb ELISA Kit |
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| MBS9510760-1x96Wells | MyBiosource | 1x96Wells | EUR 520 |
Betacellulin (Human) LumiAb ELISA Kit |
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| MBS9510760-5x96Wells | MyBiosource | 5x96Wells | EUR 2395 |
Betacellulin (HEK293-expressed)， Human |
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| HY-P7328 | MedChemExpress | 10ug | EUR 280.8 |
Human Betacellulin (bTC) Protein (Active) |
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| 20-abx655563 | Abbexa |
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Human Betacellulin (bTC) Protein (Active) |
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| abx655563-50g | Abbexa | 50 µg | EUR 3712.5 |
Nori® Human Betacellulin ELISA Kit |
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| GR106276 | Genorise Scientific | 96-well | EUR 461 |
Recombinant Human Betacellulin, His Tag |
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| cyt-077-10g | ProSpec Tany | 10µg | EUR 145 |
Recombinant Human Betacellulin, His Tag |
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| cyt-077-1mg | ProSpec Tany | 1mg | EUR 5200 |
Recombinant Human Betacellulin, His Tag |
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| cyt-077-2g | ProSpec Tany | 2µg | EUR 60 |
Recombinant Human Betacellulin, His Tag |
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| MBS144451-0002mg | MyBiosource | 0.002mg | EUR 240 |
Recombinant Human Betacellulin, His Tag |
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| MBS144451-001mg | MyBiosource | 0.01mg | EUR 310 |
Recombinant Human Betacellulin, His Tag |
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| MBS144451-1mg | MyBiosource | 1mg | EUR 5345 |
Recombinant Human Betacellulin, His Tag |
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| MBS144451-5x1mg | MyBiosource | 5x1mg | EUR 23725 |
CLIA kit for Human BTC (Betacellulin) |
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| E-CL-H0444 | Elabscience Biotech | 1 plate of 96 wells | EUR 700.8 |
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Description: A sandwich CLIA kit for quantitative measurement of Human BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant |
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Betacellulin antibody |
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| 70R-BR013 | Fitzgerald | 50 ug | EUR 312 |
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Description: Affinity purified Rabbit polyclonal Betacellulin antibody |
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Betacellulin antibody |
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| MBS535912-005mg | MyBiosource | 0.05mg | EUR 465 |
Betacellulin antibody |
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| MBS535912-5x005mg | MyBiosource | 5x0.05mg | EUR 1945 |
Betacellulin (Human) Sandwich ELISA Kit |
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| OK-0105 | Assay Biotech | 1Kit | EUR 217 |
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Description: Betacellulin (Human) Colorimetric Sandwich ELISA Kit |
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Betacellulin (Human) OmniKine ELISA Kit |
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| MBS9501832-1x96Wells | MyBiosource | 1x96Wells | EUR 500 |
Betacellulin (Human) OmniKine ELISA Kit |
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| MBS9501832-5x96Wells | MyBiosource | 5x96Wells | EUR 2300 |
ELISA kit for Human BTC (Betacellulin) |
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| E-EL-H0570 | Elabscience Biotech | 1 plate of 96 wells | EUR 640.8 |
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Description: A sandwich ELISA kit for quantitative measurement of Human BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant |
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ELISA kit for Human bTC (Betacellulin) |
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| ELK1403 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
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Description: A sandwich ELISA kit for detection of Betacellulin from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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Betacellulin Human Recombinant, His Tag |
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| rAP-0361 | Angio Proteomie | Inquiry | Ask for price |
Sheep Polyclonal anti-human Betacellulin (BTC) |
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| hAP-5047 | Angio Proteomie | 50ug | EUR 400 |
Sheep Polyclonal anti-Human Betacellulin (BTC) |
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| hAP-5649 | Angio Proteomie | 50ug | EUR 400 |
BTC (GFP-tagged) - Human betacellulin (BTC) |
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| RG202483 | Origene Technologies GmbH | 10 µg | Ask for price |
Betacellulin (bTC) Polyclonal Antibody (Human), PE |
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| 4-PAA112Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with PE. |
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Betacellulin (BTC) |
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| THP-0274 | Creative BioMart | 1 vial | EUR 3198.4 |
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Description: Protein |
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Betacellulin (bTC) Polyclonal Antibody (Human), APC |
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| 4-PAA112Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with APC. |
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Betacellulin (bTC) Polyclonal Antibody (Human), Cy3 |
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| 4-PAA112Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with Cy3. |
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Betacellulin (bTC) Polyclonal Antibody (Human), HRP |
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| 4-PAA112Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with HRP. |
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